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帕米膦酸二钠联合复方苦参注射液治疗恶性肿瘤骨转移所致疼痛的疗效
Efficacy of pamidronate disodium combined with compound matrine injection against pain due to metastatic bone malignancy
目的：探讨帕米膦酸二钠+复方苦参注射液在恶性肿瘤骨转移所致疼痛临床治疗中的应用效果。方法：择取某院于2012年8月-2016年3月期间收治的恶性肿瘤骨转移患者126例，按照患者就诊时间+个人意愿，将患者划分为治疗组与参照组，每组各63例。对参照组患者行帕米膦酸二钠治疗，在参照组患者的治疗基础上，给予复方苦参注射液。对比2组患者的临床镇痛效果。结果：治疗组患者在疼痛缓解率、血清碱性磷酸酶下降有效率、生存质量稳定率、不良反应发生率方面与参照组患者进行比较，数据组间差异明显，有统计学意义（P<0.05）。结论：在恶性肿瘤骨转移临床治疗过程中，在对患者行帕米膦酸二钠治疗的基础上，实施复方苦参注射液治疗，镇痛效果显著，有利于改善患者临床治疗效果，降低患者出现不良反应的可能性，对于进一步强化患者生存质量具有非常显著的现实意义。
OBJECTIVE To analyze efficacy of pamidronate disodium combined with compound matrine injection against malignant tumor with bone metastasis and the analgesic effects. METHODS A total of 126 patients with metastatic bone malignancy were chosen from August 2012 to March 2016, and divided into treatment group and control group according to visit time + personal opinion, 63 patients in each group. Patients in control group received the basic treatment of pamidronate disodium, and patients in treatment group additionally received compound matrine injection. Analgesic effects of two groups were compared. RESULTS Patients in treatment group had superior relief rate of pain, effective rate of decreasing serum alkaline phosphatase, stable quality of life, incidence of adverse reactions to control group (P<0.05). CONCLUSION During malignant tumor bone metastasis, pamidronate disodium combined with compound matrine injection has significant analgesic effects, is favorable for improving therapeutic effects, tends to reduce possibility of adverse reactions, and has important practical significance to further enhance quality of life for patients.
帕米膦酸二钠 / 复方苦参注射液 / 恶性肿瘤骨转移所致疼痛 / 临床疗效 {{custom_keyword}} /
pamidronate disodium compound matrine injection / pain caused by bone metastasis of malignant tumors / clinical therapeutic effects {{custom_keyword}} /
[1] Saylor PJ,Armstrong AJ,Fizazi K,et al. New and emerging therapies for bone metastases in genitourinary cancers[J].Europeanurology, 2013,63(2):309-320.
[2] Chiacchio S, Mazzarri S, Lorenzoni A,et al. Radionuclide therapy and integrated protocols for bone metastases[J]. Q J Nucl Med Mol Imaging., 2011,55(4):431-447.
[3] Liu Nan-nan,Shen Dong-lan,Chen Xiao-qiu,et al.Clinical analysis of 355 patients with bone metastasis of malignant tumors[J].Chin J Oncol,2010,32(3):203-207.
[4] Fenqiang Li,Wenhui Wang,Li Li,et al. An effective therapy to painful bone metastases:cryoablation combined with zoledronic acid[J].Pathol Oncol Res, 2014,20(4):885-891.
[5] 叶进科,吴亚丛,付静,等.复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的效果观察[J].中国综合临床,2012,28(06):579-581.
[6] 金旭东,李小强,陈莉峰,等.复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛[J].长春中医药大学学报,2013,29(6):1080-1081.
[7] 王双伟,司玉玲.帕米膦酸二钠联合复方苦参注射液治疗恶性肿瘤骨转移所致疼痛的疗效观察[J].现代药物与临床,2014,29(04):397-400.
[8] 罗波,宋保连,孙立江,等.不同剂量帕米膦酸二钠治疗前列腺癌骨转移疼痛的临床研究[J].山东医药,2010,50(01):57-58.
[9] 王凯,王栓科,赵斌,等.唑来膦酸与帕米膦酸二钠治疗恶性肿瘤骨转移疼痛:疗效与安全性对比的Meta分析[J].中国组织工程研究与临床康复,2010,14(26):4791-4795.
[10] 胡晓华,王美玲,姜斌,等.帕米膦酸二钠联合骨架型芬太尼透皮贴剂治疗肿瘤骨转移疼痛的临床观察[J].临床肿瘤学杂志,2011,16(03):265-267.
[11] 罗波,孙立江,郝建波,等.不同剂量帕米膦酸二钠治疗前列腺癌骨转移疼痛临床研究[J].中国全科医学,2010,13(24):2683-2684,2687.
[12] 李英华,王彦,李曼,等.唑来膦酸、伊班膦酸钠和帕米膦酸二钠治疗非小细胞肺癌骨转移的疗效和安全性比较[J].医学与哲学,2012,33(06):23-25.
[13] 李茹恬,王立峰,孟谊,等.帕米膦酸二钠与唑来膦酸治疗肺癌骨转移性疼痛的近期疗效及成本效益分析[J].现代肿瘤医学,2014,22(11):2718-2721.
[14] 唐新宇,周锡建,范晓强,等.高剂量帕米膦酸二钠联合硫酸吗啡缓释片治疗多发骨转移性疼痛观察[J].现代中西医结合杂志,2010,19(21):2612-2613,2687.
[15] 李东华,吴国祥,徐怀昌,等.复方苦参注射液联合帕米膦酸二钠治疗骨转移瘤疼痛的疗效[J].西北药学杂志,2015,02(03):289-292.
中国药学会科技开发中心委托研究项目（编号：2012DCST010T4）
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